Research Is Hopeful About CBD and Depression

Researchers have found that with only one dose of CBD both mice and rats experienced “acute antidepressant effects”. This was due to increased levels of proteins in their brains’ medial prefrontal cortex and the hippocampus. So basically, it made the mice feel much less behavioral despair when put through certain stress tests.

Those findings are that of a study which was published this year in the journal of Molecular Neurobiology by researchers from the University of Sao Paulo in Brazil as well as Aarhus University Hospital in Denmark. In these studies CBD is being used in animal testing in order to prepare for human testing.

Quote stated by the researchers:  “The main finding of the present study is that CBD induces not only a robust acute, but also sustained, antidepressant-like effects in different species and distinct animal models.”

So why should CBD be Studied for depression?

After reading these studies we wanted to know why put mice and rats through tests with CBD? Well according to researchers, these tests into CBD’s impact on despondency are driven by the desire to find alternatives to prescription drugs for depression. Although these over the counter and prescription drugs are effective in many cases, those who take drugs for depression risk a number of side effects. Information taken from Web MD, shows some of the common side effects from antidepressant drugs including:

  • Nausea
  • Increased appetite and weight gain
  • Loss of sexual desire
  • Erectile dysfunction
  • Decreased orgasm
  • Fatigue and drowsiness
  • Insomnia
  • Blurred vision
  • Constipation
  • Agitation
  • Irritability
  • Anxiety

Wow, that is a long list. Analysts also noted that the “currently available antidepressants have a substantial lag in time before inducing a therapeutic response as well as having a relatively low efficacy. The development of more natural and beneficial drugs which address these limitations is critical to improving public health.”

What are the findings of these studies?

The study we referred to at the beginning of this article put mice and rats through various tests after receiving a small dose of CBD. These tests included forced swimming test’s (FST), which is done by placing the animals in a container filled with water. The F.S.T. is based on the assumption that animals will make efforts to escape but eventually exhibit immobility that researchers assume reflects behavioral despair. This in turn exposes the animals to stress, which has been shown to be a major contributor in depression.

The forced swimming test and other tests have found that the animals showed less depressed behavior, perhaps due to the increased levels of proteins and the neurotransmitter serotonin in the brain. They also noted that this effect seemed to happen quickly.

These aren’t the first studies to show this.

A study from 2014 led by researchers at the Laboratory of Panic and Respiration at the Federal University of Rio de Janeiro recognized some of these issues. This study, which also involved mice, went into detail on how depression manifests in the brain. This is what researchers wrote –  “depressed patients present symptoms such as mood changes, apathy, lack of ability to feel pleasure, increased levels of irritability, prostration, cognitive and psychomotor changes and changes in appetite and sleep regimen.”

What they found was that CBD interacted in a positive way with the serotonin receptors in the brain. Serotonin is believed to be a major impact on a person’s emotional state & feelings of well-being or happiness.

Very much like recent studies, researchers in the 2014 tests also found that CBD “exhibited an anti-anxiety and antidepressant effect in animal models.”

All in all, based off of the research done as of late and in the past we can conclude that CBD may just be the help you need for your depression and or anxiety.

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